Tag: LC/MS

Research Associate-II || Waltham, MA || Type-1-Year Contract ||$40-45/hr

ashishsisodiya45 August 18, 2020
Job Role- Research Associate II

Employment Type-1-year contract
Pay rate-$40-45/hr
Location-Waltham,MA
Description:

 

Responsibilities:
• Perform in vitro and in vivo drug metabolism studies for discovery projects in various Sanofi R&D portfolios
• Prepare routine in vitro samples for metabolism identification studies including but not limit to incubation with hepatocytes, liver microsomes or other biological matrices
• Operate and maintain LC/MS systems
• Aid in performing routine tissue exposure and binding studies for LC-MS analysis
• Assist metabolism group in maintaining documentation, safety inspection, and instrument logbooks.
• Maintain general lab reagents and supplies inventory

Basic Qualifications:
• BS or MS in biology, chemistry, or pharmaceutical science discipline with experience in conducting drug metabolism studies using hepatocytes and liver microsomes
• Strong technical skills in handling hepatocytes, cells, and other biological matrices
• Experience in operating and maintaining LC and Thermo Scientific Orbitrap or AB Sciex triple-quadruple mass spectrometers
• Prior experience in Analyst® software for quantitative analysis and automation using Tecan liquid handling system for drug metabolism assays is a plus

Preferred Qualifications:
• Attention to details
• Critical analytical and problem solving skills
• Excellent communication and interpersonal skills
• Strong commitment to the assigned tasks and striving for on-time delivery
• Desire to work within a team in a highly dynamic environment
 
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Research Associate-II || Waltham, MA || Type-2-Year Contract ||$40-45/hr

ashishsisodiya45 August 1, 2020
Job Role- Research Associate II

Employment Type-2-year contract
Pay rate-$40-45/hr
Location-Waltham,MA

Job Specific Duties:

Perform formulation screening, prepare and characterize dosing formulations for animal studies. Conduct HPLC method development and samples analysis of small molecules in support of discovery formulation development. Measure protein concentration of monoclonal antibodies to support biotherapeutic programs. Troubleshoot analytical instrumentation and solve technical problems. Independently conduct formulation research and process improvement as needed. Interpret results and write technical reports. Responsible for general laboratory maintenance, buffer preparations, labeling, packaging and shipping of outgoing materials.

Skills:

HPLC, SEC, UV and LC/MS
Microscopy
Particle size analysis
Experience with solubility, stability studies and formulation screening.
Ability to multi-task and work efficiently in a fast paced and dynamic environment.
Ability to manage multiple projects while maintaining efficiency and effectiveness.
Ability to independently design experiments and conduct formulation research.
Excellent organizational and communication skills.
Ability to work independently and in a team environment.

Education:

MS (with 0-5 years related experience) in pharmaceutical sciences or analytical chemistry.

General Duties:

Responsible for the execution and analysis of experiments and analytical procedures. Display an investigative or technological orientation in designing, executing and interpreting experiments and analytical procedures. Investigate basic technical problems and performs routine scientific procedures and experiments under general supervision. Plan and prioritize concurrent experimental procedures. Integrate, compile, and tabulate data and assist supervisor in the analysis and interpretation of the results. May provide oral presentations on results to other department members. Contribute to the completion of milestones associated with specific projects. Frequent internal company contacts. Infrequent inter- departmental and outside constituent contacts on routine matters. 

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